Currently pinentry-gtk2 (don't know about the -qt version), by default, grabs the keyboard and mouse, preventing the user from accessing a password manager.
I can see how that could be a security feature, but there's a difference between preventing another window from popping into focus in the middle of entering a secret and preventing the user from doing ANYTHING other than typing in the pinentry window. If the user can't type in the secret, this feature effectively forces whatever operation caused pinentry to be invoked to fail, the consequences of which could range from none to catastrophic.
Now, I realize the -g/--no-global-grab option exists, but I couldn't find a way to enable it globally and pinentry, once invoked, doesn't offer a way to disable it either.
This bug report is not about the validity of the keyboard/mouse grabbing concept, but about the global default and/or the ability to change the setting globally, or in the pinentry window.