gpgconf writes something like the following into configuration files:

###+++--- GPGConf ---+++### Di 01 Jun 2021 11:12:52 CEST
# GPGConf edited this configuration file.
# It will disable options before this marked block, but it will
# never change anything below these lines.

Options below these lines are not reported as read-only (or "no change (128)") although they cannot be changed via gpgconf. Therefore Kleopatra shows those options as editable although they are only editable manually in the configuration files.