In T6336#166815, @werner wrote:

Actually, the entire systemd based launching is deprecated and thus the logged warning is on purpose.

The problem with the systemd launched gpg-agent is that it creates a race: gpg launches gpg-agent as needed and to avoid concurrent launching by other gpg or gpgsm processes, it takes a file system lock during the launch process. systemd does not know about this and we end up with sometimes end up with two gpg-agent processes. Eventually one of those processes detects that it does not own the socket and terminates itself. No real harm here but you may see smart card lockups or a flushed password cache.