I added "disable-check-own-socket" to gpg-agent.conf .
Since 8 hours no "hanging".
I will watch it furthermore...

Is there a more detailed logging that i can switch on? Perhaps i can help you to get diagnostic files. Nearly every day i notice this bug. In the log (with "verbose" in gpg-agent.conf) are the same entries i already posted.

Do you have any idea about this issue?
Exactly same behaviour here.
Windows 7 Enterprise 64-Bit, Outlook 2010 (Version 14.0.7188.5002, 32-Bit), GpgOL 2.0.1
Tell me if you need any diagnostic logs, ...

... gpg-agent hangs. After cancelling the process it works again ...

gpg-agent.conf actual content:

Just to inform that it is not a single problem.
I recognized exactly the same behaviour.
After terminating the gpg-agent task everything works as aspected (up to the next non-activity phase).
64-bit Windows 7 Enterprise, Outlook 2010, GPG4Win Version 3.0.0-gpg4win-3.0.0.