On further thought, it's possible that something closer to what
Bernhard wants (and incidentally more along the lines of what I was
thinking of in some of our discussions just after the initial port)
might be achievable with Cython.

CFFI has no real means of generating the needed bindings on the fly
like SWIG does, except via its ABI methods, but those are inferior to
what SWIG does. It also can't handle all the ifdefs (or really any of
the ifdefs) in gpgme.h.

GPGME 1.12.1-beta43 is nowhere near the current master. Current is around 1.12.1-beta130 (or above) and beta 43 would've been months ago, probably early November or late October.